Lehigh University
Lehigh University


Closing the loop

Roy Loya (seated) is learning to control his brain signals with help from Sarah Ying (left).

Mayuresh Kothare

Roy Loya is a tax attorney who has piloted airplanes, worked as an aeronautical engineer and traveled to most of the corners of the world.

Today, sitting perfectly still with 64 electrode sensors attached to his scalp, he is summoning the waning powers of his mind.

Loya has struggled for 10 years with ataxia, a degenerative condition that robs the brain of its ability to coordinate the body's fine motor movements. He cannot stand on his own, walk or hold a pen. His speech is slurred and raspy.

But Loya is conceding nothing to illness. Today, guided by a team of researchers, he is marshaling his brain signals to do what his body no longer can.

Without flexing a muscle, Loya imagines he is moving his right hand. This generates brain signals, which are conveyed to an amplifier and an electroencephalograph (EEG). A computer processes the signals and carries out their intention. The results play out on a 40-inch TV, where a cursor inches down from the middle of the screen until it hits a rectangular target at the bottom.

Loya next focuses mentally on a left-hand motion, and the cursor moves slowly toward a target at the top of the screen.

Loya is seated in a neuroengineering lab at Johns Hopkins University's School of Medicine. Minutes pass as he performs each task. Six researchers stand quietly around him, moving only to read the signals displayed on the computer or to adjust the signal-processing software.

The research team is led by Sarah Ying and Nitish Thakor of Johns Hopkins and Mayuresh Kothare of Lehigh. Ying, an assistant professor of neurology and ophthalmology at the Johns Hopkins Hospital, is an expert in ataxia, dizziness and eye movement abnormalities.

She has worked with Loya for seven years. Thakor, professor of biomedical engineering and neurology, directs Johns Hopkins' Neuroengineering and Biomedical Instrumentation Lab. Kothare, an expert in control systems, is professor of chemical engineering at Lehigh.

The researchers' goal is to help Loya and others like him learn to use brain-computer interface (BCI) technology to regain control of functions they have lost due to brain damage or disease. They are focusing on the feedback mechanism that enables the cerebellum to correct for errors while executing extremely precise multijoint movements. Located at the base of the brain, the cerebellum contains more than half the brain's neurons (brain cells) but takes up only 10 percent of its volume. It integrates sensory perception, coordination and motor control, and signals the cortex, the outermost layer of the brain, to command muscles to move.

Scientists and engineers have developed BCIs that signal actuators to move cursors and operate artificial hands and other neuroprosthetic devices. Thakor's lab has helped trans-radial (below-the-elbow) amputees control prosthetic hands that are linked to the signals generated by the muscles on their residual limbs. In another project, his group decodes brain signals to command prosthetic hands to open and close.

But little research has been done to enable BCIs and neuroprostheses to respond as the cerebellum does to sensory feedback from the environment. A driver changing lanes on the highway and an outfielder chasing a fly ball must adjust to changes in the environment and in their perception of the environment. Similarly, as a hand reaches for a cup, "force feedback" from the hand and visual feedback from the eye tell the cerebellum how much farther and in what direction the hand must move to complete its task. The cerebellum processes this feedback and sends new signals ordering the hand to take corrective action.

It is this feedback process that the Lehigh-John Hopkins team is seeking to interpret and to model mathematically. "Force, visual and all other kinds of feedback influence how the brain changes its signals," says Kothare. "We want to interpret these modified signals and convert them into action. "To do that, we have to understand the entire closed loop. This includes the brain signals, the interpretation of the signals, the implementation of the brain's command, the feedback by sensors to the brain, and the transmission of new brain signals that are modified in response to the environment.  We want to measure and model this entire system."

Three-way serendipity 

The idea for the Lehigh-Johns Hopkins collaboration originated when Kothare and Thakor met at a reunion of alumni from the India Institute of Technology and discovered a common interest in neuroengineering.

"I have always been interested in control theory and feedback and its impact on learning," says Kothare, who previously engineered a chip-based microreactor that catalyzes methanol into hydrogen and also investigated an implantable device for insulin delivery.

In 2008, Kothare and Thakor became one of about 30 teams out of 1,250 competing to win a grant through NSF's Cyber-Enabled Discovery and Innovation (CDI) initiative. The three-year award has partially supported Kothare's sabbatical at Johns Hopkins' School of Medicine.

Two months into the project, Kothare met Ying when she proposed a project using BCIs to study ataxia patients and other persons with cerebellar defects. Ying secured approval to do studies on actual subjects, while Kothare obtained certification from the Johns Hopkins Institute Review Board. Thakor, who is an investigator for DARPA's Revolutionizing Prosthesis Program, already had a lab set up for BCI research and EEG monitoring.

Kothare then recruited Geoffrey Newman, a graduate student in biomedical engineering at Johns Hopkins, and Youngseok Choi, a postdoctoral neuroengineer who develops neurological signal analysis methods for brain injuries. Choi, a visiting researcher at Johns Hopkins, now oversees signal processing for the ataxia project. Newman has helped modify a previously developed BCI hardware-software platform and equip it with an interface that runs the cursor-target experiments.

Profound and life-altering 

Ataxia comes from two Greek words - a, meaning without, and taxis, meaning order. An estimated 150,000 Americans suffer from the condition, according to the National Ataxia Foundation, and they include men and women, young and old, and members of every racial and ethnic group.

Often hereditary, ataxia is a set of symptoms that result from disease, defects or damage to the cerebellum. It afflicts fingers, hands, legs, balance, speech and eye movements, and it is degenerative. From slurred speech and unsteady balance, patients typically progress to the point at which the simplest tasks require the utmost will power.

Many types of ataxia, including Loya's, do not shorten a person's life, says Ying, who has worked a decade with ataxia patients. But ataxia in all its forms alters life profoundly.

"Ataxia is socially very isolating. Ataxia patients can't speak well and they can't move around. They spend a lot of time on the Internet, but may have difficulty typing."

BCI technology promises to restore some social life by helping ataxia patients perform activities that can be interfaced with a computer, says Ying. These could include operating a wheelchair or using prosthetic limbs. But scientists must first improve their ability to interpret and harness brain signals.

That endeavor is daunting. The brain's 100 billion cells make thousands of connections with each other every second. To probe this activity with 64 electrodes, says Thakor, is like asking space aliens who know nothing of human beings to observe the earth and summarize all of its intelligent life from 64 orbiting satellites.

But electrodes placed on the functioning part of the sensory and motor cortex would allow scientists to capture the cortical signature, says Thakor. Humans could then learn to control the signals in this region of the brain by modulating the frequency of those signals, much as a soprano renders an aria by modulating the pitch of her voice.

One question yet to be answered, says Ying, is whether ataxia patients can control their brain signals as well as normal people. Can they perform as well on the cursor-target exercise and other brain signal tests? Ying is correlating those test results with MRI scans to determine if anatomical clues might predict the ability of Loya and other ataxia patients to master BCI technology.

The research team is also planning a set of experiments to measure the impact of feedback on the transmission of brain signals. The team will implant electrodes on the cortices of epilepsy patients undergoing surgery for seizures. The electrodes will enable the researchers to obtain a "neural signature" by recording the brain signals that are generated when a postsurgery patient performs a routine task. The goal is to observe how that signature changes with and without visual feedback.

"We will ask the person to close his eyes and reach for an object," says Kothare. "Without the benefit of visual feedback, the person will have to rely on force feedback, along with the memory of the position of the object, to accomplish the task. Then we will tell the person to open his eyes and reach for the object. We will watch the progress of the person's arm toward the object while we measure the neural signals being emitted.

"Our hypothesis is that the signals generated by the brain during each of these scenarios will be different. This hypothesis has never been tested in an experiment. We hope to understand how neural signals change as feedback occurs."

"Any way I can"

Back in Johns Hopkins' neuroengineering lab, Roy Loya has completed the two-hour brain signal exam. After seven years of MRIs, movement studies, gait testing and cognitive exams, this has been Loya's first trial with BCI technology. In addition to the cursor-target test, he has also attempted to modulate his brain waves by thinking calm or agitated thoughts. The day has been a qualified success. Loya did well for an hour, then tired. And the researchers need to work on the signal-processing software and refine an algorithm to achieve a better balance between left and right hand.

Loya's handshake is firm as he says good-bye to the researchers, and his face is alert. He begins to reminisce, moving his hands alongside his neck to improve control over his vocal cords. His words rumble out, each the product of great effort. But he makes himself understood.

As a young man, Loya completed a bachelor's degree in aeronautical engineering from Princeton. He went to law school at the University of Maryland and at Georgetown. He practiced tax law for 20 years and traveled to 70 countries on six continents. He earned a pilot's license and flew the Douglas DC-3, a propeller-driven transport plane used in World War II.

Loya did not notice his first symptom of ataxia until eight years ago, when air-traffic controllers began having trouble understanding his speech. Now he has one goal.

"I have always loved science. I want to help these people any way I can."

Story by Kurt Pfitzer

Posted on Wednesday, January 27, 2010

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